Last edited by Dagal
Tuesday, August 4, 2020 | History

1 edition of Individual Susceptibility to Genotoxic Agents in the Human Population found in the catalog.

Individual Susceptibility to Genotoxic Agents in the Human Population

by Frederick J. Serres

  • 225 Want to read
  • 33 Currently reading

Published by Springer US in Boston, MA .
Written in English

    Subjects:
  • Physics

  • Edition Notes

    Statementedited by Frederick J. Serres, Ronald W. Pero
    SeriesEnvironmental Science Research -- 30, Environmental science research -- 30.
    ContributionsPero, Ronald W.
    Classifications
    LC ClassificationsQC1-75
    The Physical Object
    Format[electronic resource] /
    Pagination1 online resource (518 pages).
    Number of Pages518
    ID Numbers
    Open LibraryOL27045182M
    ISBN 101461327652
    ISBN 109781461327653
    OCLC/WorldCa840281801

    IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans Richard J. Albertini a, to monitor groups or individuals exposed to genotoxic agents. Most human carcinogens are genotoxic but not all genotoxic General considerations relating to all genotoxic-ity endpoints Inter-individual biological variability affects both.   Examples of environmental factors that have been associated with increased cancer risk in the human population include chemical and physical mutagens (e.g. cigarette smoke, heterocyclic amines, asbestos and UV irradiation), infection by certain viral or bacterial pathogens, and dietary non-genotoxic constituents (e.g. macro- and micronutrients).Cited by:

    Individual Susceptibility to Genotoxic Agents in the Human Population. New York, NY: Plenum Press. p Waters MD, Claxton LD, Stack HF, Brady AL, Graedel TE. genotoxic carcinogens: cancer-causing agents that can alter deoxyribonucleic acid (DNA) molecules. Genotoxic carcinogens include organic compounds that induce mutations directly, organic compounds that alter DNA after activating metabolism, and metals or metal salts that can alter DNA.

    Methods for Evaluating Potential Carcinogens and Anticarcinogens Carcinogenic activity in rodents, following the oral administration of certain dyes, was first demonstrated in the early s. Since then, numerous experimental studies have been conducted to identify carcinogens in the diets of humans.   We hypothesized that in Flanders (Belgium), the prevalence of at-risk genotypes for genotoxic effects decreases with age due to morbidity and mortality resulting from chronic diseases. Rather than polymorphisms in single genes, the interaction of multiple genetic polymorphisms in low penetrance genes involved in genotoxic effects might be of relevance. Genotyping was performed on Cited by: 7.


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Individual Susceptibility to Genotoxic Agents in the Human Population by Frederick J. Serres Download PDF EPUB FB2

Individual Susceptibility to Genotoxic Agents in the Human Population. Authors: De Serres, Frederick J., Pero, Ronald W., Sheridan, William Free PreviewBrand: Springer US. Individual Susceptibility to Genotoxic Agents in the Human Population in recent years for us to determine that there are mutagenic agents among thou­ sands of chemicals to which the human population is exposed today.

and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as. Buy Individual Susceptibility to Genotoxic Agents in the Human Population (Environmental Science Research) on FREE SHIPPING on qualified orders Individual Susceptibility to Genotoxic Agents in the Human Population (Environmental Science Research): De Serres, Frederick J.: : Books.

Individual Susceptibility to Genotoxic Agents in the Human Population (Environmental Science Research (30)) th Edition by Frederick J.

De Serres (Author), Ronald W. Pero (Author), William Sheridan (Author) & 0 moreCited by: "Proceedings of a workshop on individual susceptibility genotoxic agents in the human population, held May, at the National Institute of Environmental Health Sciences, in Research Triangle Park, North Carolina." Description: x, pages: illustrations ; 26 cm.

Contents: Session I: Genotoxic Substances and Variability in Human. Get this from a library. Individual Susceptibility to Genotoxic Agents in the Human Population. [Frederick J Serres; Ronald W Pero] -- As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but.

You can create not one individual susceptibility to genotoxic agents in the human population of a disabled Access left app in a SharePoint order., ;Robbie Sweeney individual susceptibility to genotoxic(work their ideology may see their ease committed from new employee.

language(This Source is not last when embedded in the /5. Waters M.D. et al. () Evaluation of Genotoxic Effects in Human Populations. In: de Serres F.J., Pero R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol Cited by: 3.

Language: English ISBN:LCCN: MeSH: Mutagenicity Tests*; Mutagens/adverse effects* Publication Type(s): Congresses Notes: "Proceedings of a workshop on individual susceptibility to genotoxic agents in the human population, held May, at the National Institute of Environmental Health Sciences, in.

Genotoxic thresholds, DNA repair, and susceptibility in human populations Article Literature Review in Toxicology (3) November with 17 Reads How we measure 'reads'. Individual susceptibility to induced chromosome damage and its implications for detecting genotoxic exposures in human populations.

Wiencke JK(1), Wrensch MR, Miike R, Petrakis NL. Author information: (1)Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco Cited by:   In genetic toxicology a linear dose–response relationship has long been assumed to apply for direct acting genotoxic agents (Henderson et al., ).Fig.

1 displays the different theoretical dose–response relationships for genotoxins (linear and thresholded). In the linear model, DNA damage induction is believed to be directly proportional to dose; leading to the implication that there are Cited by: Individual Susceptibility to Genotoxic Agents in the Human Population Frederick J.

De Serres,Ronald W. Pero,William Sheridan — Science Author: Frederick. 1 Genotoxic thresholds, DNA repair, and susceptibility in human populations Gareth J.S. Jenkins∗, Zoulikha Zaïr, George E.

Johnson, Shareen H. Doak 2 3 Q1 Institute of Life Science, Swansea School of Medicine, Swansea University, Medicine, Singleton Park, Swansea SA28PP, United Kingdom 4 5 article info 6 7 Article history: 8 Received 4. leading causes of death in the human population1,2.

classification as positive or negative for genotoxic potential. Most human carcinogens are identified by epidemiological studies.

These studies are necessarily Review on Genotoxicity, its Molecular Mechanisms and Prevention A Review Article. Int. Pharm. Sci. Rev. Res., 22(1), Sep File Size: KB.

Molecular Epidemiology of Human Cancer: Biomarkers of Genotoxic Exposure and Susceptibility Article (PDF Available) in Journal of Environmental Pathology Toxicology and Oncology 20(4) Author: Stephen G Grant.

Discover Book Depository's huge selection of William Sheridan books online. Free delivery worldwide on over 20 million titles. Individual Susceptibility to Genotoxic Agents in the Human Population. Frederick Serres. 22 Feb Paperback.

US$ Genotoxicity is the process by which an agent produces a deleterious effect on DNA and other cellular targets that control the integrity of genetic material [17]. François Gagné, with the contribution of Émilie Lacaze, Sylvie Bony and Alain Devaux, in Biochemical Ecotoxicology, The Comet assay requires a very small sample of any.

Assignment on Genotoxicity 1. INTRODUCTION Mutation is a broad term covering a whole range of changes to the informational molecule, DNA (made up of the four nucleotides: the purines, adenine and guanine, and the pyrimidines, thymine and cytosine) packaged into chromosomes, of an organism from gene changes to modifications of the number and structure of chromosomes Point.

Epigenetics application in toxicology • Identify chemicals with potential to cause adverse effects • Elucidate mechanisms of action and affect weight of evidence conclusions • Categorize compounds by mechanistic class • Rank by relative potency and epigenetic signature • Assist in identifying susceptible populations and life stages • Use biomarkers of exposure and/or effects.

A guide to the concepts and principles governing the use of biomarkers to assess the risks to human health posed by exposure to chemical agents. Emphasis is placed on criteria for the selection and validation of appropriate biomarkers of exposure, of toxic effect, and of susceptibility in either individuals or sub-populations.Susceptibility is critical to an understanding of coal diseases, including cancer, and many xenobiotic agents act to alter susceptibility.

Unknown individual susceptibility, inadequate toxicity data, and the unpredictable nature of interaction effects make the implementation of a human biomonitoring assessment for complex mixtures of chemicals Cited by: 3.Induced Effects Of Genotoxic Agents In Eukaryotic Cells - CRC Press Book This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure.